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B-LACTAMS – Penicillins

Created: 30/5/2007
Updated: 30/5/2007
 

Penicillins

Mechanism
Inhibit cell wall synthesis by damaging transpeptidases
Activity depends on intact penicillin B-lactam ring
Resistance from bacteria producing B-lactamase

Spectrum
Gram +ve bacteria

Especially

  • Streptococcus
  • Pneumococcus
  • some Staphylococcus

Drugs

Penicillin G

  • Dose 600mg – 1.2g QID IV

Ampicillin

  • Strep faecalis
  • H influenzae
  • coliforms
  • Dose 500 mg QID IV

Amoxycillin

  • Strep faecalis
  • H influenzae
  • Coliforms
  • Dose 500mg – 1g QID IV

Flucloxacillin

  • Stable against staph’s B-lactamase
  • Dose 1 – 2 g QID IV

ArticleDate:20070530
SiteSection: Article
 

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