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B-LACTAMS - Carbapenems

Created: 30/5/2007
Updated: 30/5/2007
 

Carbapenems

Mechanism
As penicillin, but more B-lactam stable
Drug itself is a B-lactamase inhibitor

Spectrum
Very broad
G +ve and G –ve
Useful in empirical therapy, especially if multi-organism cause

Drugs 

Imipenem

  • Rapidly metabolised by kidney so given with an enzyme inhibitor cilastin
  • Dose 500 mg QID IV

Meropenem

  • Proably better for CNS infections
  • More expensive than Imipenem
  • Dose 500 – 1000mg TDS IV

ArticleDate:20070530
SiteSection: Article
 

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