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B- LACTAMS - Cephalosporins

Created: 30/5/2007
Updated: 30/5/2007
 

Cephalosporins

Mechanism
Damage the cell wall like penicillins
Progressive generations are more B-lactam stable, but have worse anti-staph activity (due to less avid binding)

Spectrum
Wide range of G +ve and G-ve bacteria
3rd Generation are active against Pseudomas (especially Ceftazidime)

Drugs

Cefuroxime

  • Second generation
  • Reasonable G+ve and G-ve activity
  • Dose 750mg – 1.5g TDS

Ceftriaxone

  • Third generation
  • Better G -ve cover, but worse G +ve cover
  • Dose 1-2 g OD IV

Cefotaxime

  • Third generation
  • Better G -ve, but worse G +ve cover
  • Dose 1 – 2 g BD IV

Fourth Generation have extended G+ve and G-ve cover


ArticleDate:20070530
SiteSection: Article
 

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