Developed from Nalidixic acid
Inhibit DNA Gyrase and interfere with DNA replication.
- Active against G-ve aerobes including pseudomonas and staph
- Generally poor against Strep and anaerobes
- Caution - fluroquinolones reduce metabolism of theophyllines and warfarin and lower the seizure threshold
- Dose 400mg BD IV
- Dose 500mg BD O