Multicenter, randomized, controlled clinical trial
Hebert PC, Wells G, Blajchman MA et al. Canadian Critical Care Trials Group.
A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care.
New England Journal of Medicine 1999; 340: 409-417.
A restrictive strategy of red-cell transfusion (hemoglobin concentrations maintained at 7.0 to 9.0 g/dl) is at least as effective as and possibly superior to a liberal transfusion strategy (hemoglobin concentrations were maintained at 10.0 to 12.0 g/dL) in critically ill patients. A possible exception to this recommendation are patients with acute myocardial infarction and unstable angina.
Point for discussion:
Given the type of patients enrolled into the trial, can this recommendation be safely extrapolated to critically ill patients with ARDS and multi-organ failure?