Search our site 
 
Advanced Search
 
Home | News | Exam dates | Contact us | About us | Testimonials |
 
 

map

A randomised study of magnesium sulphate as an adjuvant to intrathecal bupivacaine in patients with mild preeclampsia undergoing caesarean section - 14/4/2010


Int J Obstet Anesth 2010; 19: 161-6

Introduction

Intrathecal magnesium, an NMDA antagonist, prolongs analgesia without significant side effects in healthy parturients. These authors studied the effect of adding intrathecal magnesium sulphate to bupivacaine-fentanyl spinal anaesthesia in patients with mild pre-eclampsia undergoing Caesarean section.

Methods

This prospective, double-blind, placebo-controlled trial recruited 60 women with mild pre-eclampsia undergoing Caesarean section. Patients were randomly assigned to receive spinal anaesthesia with 2 ml 0.5% hyperbaric bupivacaine and 25 µg fentanyl with either 0.1 ml 0.9% sodium chloride (control group) or 0.1 ml 50% magnesium sulphate (50 mg) (magnesium group). The onset, duration and recovery of sensory and motor block, time to maximum sensory block, duration of spinal anaesthesia and postoperative analgesia requirements were studied.

Results

The onset of both sensory and motor block was found to be slower in the magnesium group. The duration of spinal anaesthesia (229.3 versus 187.7 minutes) and motor block (200 versus 175.3 minutes) were significantly longer in the magnesium group. Diclofenac requirement for 24 hours following surgery was significantly lower in the magnesium group (147.5 versus182.5 mg; p=0.02). Haemodynamic parameters and side effect profile were similar in the two groups.

Conclusions

The authors conclude that, in parturients with mild pre-eclampsia undergoing Caesarean delivery, the addition of magnesium sulphate 50 mg to the intrathecal combination of bupivacaine and fentanyl prolongs the duration of analgesia and reduces postoperative analgesic requirements without additional side effects.



Click here to return to the main Journal page


ArticleDate:20100414
SiteSection: Abstracts



 
All rights reserved © 2014. Designed by AnaesthesiaUK.

{Site map} {Site disclaimer} {Privacy Policy} {Terms and conditions}
This site complies with the HONcode standard for trustworthy health information:
verify here. 

 Like us on Facebook 
This website is certified by Health On the Net Foundation. Click to verify.

vp